Centre dâ€™Ă©tudes des Maladies Infectieuses et Pharmacologie Anti-Infectieuse
BSL-3 Research Platform
A 232 m2, fully equipped BSL-3 research facility on the CNRS campus in Montpellier is available to academic and corporate scientists for studies involving BSL-3 agents.
CEMIPAI has over 350m2 of Biosafety Level 2 and Biosafety Level 3 laboratory space (BSL-2 and BSL-3). These labs are fully equipped for in vitro viral and bacterias culture and assays. We also provide BSL-3 high-containment drug discovery services for evaluations of new therapeutics in the rapidly evolving fields of vaccines development, antiviral compounds, immunotherapy, gene therapy and cell therapy. Partnerships with Montpellier Universityâ€™s animal biosafety lab (ABSL-3) form a full R&D pre-clinical value chain for efficacy studies.
Highly Experienced Personnel
In vitro studies conducted in our BSL-2 and BSL-3 facilities are directed by virologists and bacteriologists, with extensive experience in high-containment laboratories for research and select agent studies. Our technical staff is highly trained and experienced for conducting biosafety level 2 or 3 studies in infectious disease.
Full Suite of Supporting In Vitro Assays
Our in vitro assay support services are available for semi-automated drug screening against a growing number of viruses. We offer assay development, validation and performance verification. Learn more about our BSL-3 in vitro assays and virus production services
Unique BSL-3 imaging facilities
In addition to the research suites, our BSL-3 facility includes a shared instrument room. This space houses a photonic microscopy facility (Spinning Disk and TIRF video-microscopy for PALM/STORM super-resolution imaging), a high-speed Atomic Force Microscopy coupled with fluorescence microscopy and a videodrop for virus quantification and analysis.
CEMIPAI’s containment facility includes 8 stand-alone research suites; each consisting of a microbiology research laboratory, with secure access through a common ante-room. The microbiology laboratory is a fully equipped research space which may be used for cell culture and standard microbiology experiments (vortexers, water baths, etc). Each laboratory is equipped with:
- Â biological safety cabinets
- CO2 incubators
- bacteriological incubators and shakers
- -80-degree freezer
- -20-degree freezer and refrigerator
- digital inverted fluorescence microscopes
- refrigerated centrifuge with safety enhanced rotor cups and adapters
Either only one of the 16 Biological Safety Cabinets can be rented, or a full suite containing 3 Biological Safety Cabinets and the required equipment.
CEMIPAI offers ‘Ă la carte’ services :
- Class 3 Bacteria production
- Class 2 & 3 viruses production
- In vitro assays for antiviral research: small molecules and antibody screening :Â
- CHIKUNGUNYA Virus
- ZIKA Virus
- DENGUE Virus
The imaging platform is divided into two sections, sample preparation and BSL3 microscopes for the study of live infectious samples
Sample staining for optical microscopy, Immunofluorescence
Production of EPON resin blocks, semi-fine sections and preparation of grids for transmission electron microscopy (TEM)
- 1 Nikon Ti-E video-nanoscope equipped for TIRF mode and PALM/STORM super-resolution microscopy
- 1 Zeiss Axio Observer 7 with Yokogawa spinning disk
Atomic Force Microscopy
- 1 JPK/BrĂĽker Nanowizard 4 Atomic Force Microscope coupled with a Nikon Ti-U fluorescent microscope
- 1 interferometer Neville by Myriade
Acquire or renew the knowledge necessary for class 3 pathogens handling and good practices in BSL-3. CEMIPAI’s containment laboratory training program provides courses for all personnel groups :
- laboratory staff
- biosafety professionals
- first responders
- operations & maintenance personnel
- FormationÂ CNRSÂ Entreprises